Semax

Semax is a seven-residue synthetic peptide built from two parts. The first four residues, Met-Glu-His-Phe, correspond to a fragment of adrenocorticotropic hormone. The final three, Pro-Gly-Pro, are a synthetic addition whose stated purpose in the design literature is to slow enzymatic breakdown of the peptide.

That design choice is the interesting part chemically. Proline-rich termini resist common exopeptidases, so appending Pro-Gly-Pro extends the useful lifetime of an otherwise very short peptide. The approach recurs across the Russian peptide-design programme that produced Semax and its relatives.

Despite deriving from an ACTH fragment, Semax is described in the literature as lacking the corticotropic activity of the parent hormone — the retained fragment is outside the region responsible for that effect. This is a point worth stating precisely, because the ACTH association is often misread.

Semax has a substantial Russian-language literature and a smaller indexed English-language one. The dominant research themes are expression of neurotrophic factors, particularly brain-derived neurotrophic factor, and neuroprotection in ischaemia and stress model systems, generally in rodents or cell culture.

A practical caveat for anyone reviewing this evidence: much of the foundational work predates current reporting standards and is not indexed in the databases most researchers search first. Claims about Semax that circulate online frequently trace back to sources that are difficult to retrieve and evaluate. Treat the accessible preclinical record as the evidence base and read the rest with care.

Semax is registered as a medicine in Russia. It is not approved in the UAE, the United States or the European Union, and VaultLabs supplies it strictly as a research material irrespective of its regulatory status elsewhere.

Release is by reversed-phase HPLC against a stated purity specification, with the certificate tied to the vial lot number. The methionine residue at position one is the notable analytical feature: methionine is readily oxidised, and the oxidised form is a common related substance to look for in the chromatogram.

That same sensitivity drives the handling advice. Store sealed lyophilised vials at 2–8 °C protected from light, minimise open-vial time, and avoid conditions that promote oxidation once the material is in solution. Equilibrate vials to room temperature before opening to prevent condensation onto the cake.

After reconstitution, prepare close to the point of use, log the diluent and reconstitution date, and keep freeze-thaw cycles to a minimum. The certified purity applies to the released lyophilised material, not to a solution held over time.

Semax supplied by VaultLabs is a research reference material and is not supplied for human or veterinary use. Its registration as a medicine in another jurisdiction does not change that, and it confers no permission to use VaultLabs material in a person.

The catalog presentation is a 10 mg lyophilised vial held under controlled cold storage before dispatch, with lot-linked certificate retrieval through the batch verification tool.

Neuronal culture viability assays

BDNF expression panels

Ischemia-reperfusion models (preclinical)

Cognitive behavior models (rodent literature)

2–8 °C (lyophilized, sealed)

2–8 °C for sealed lyophilized vials. Avoid freeze-thaw on prepared solutions unless validated in your workflow.

Lyophilized Semax is stable when sealed and cold-stored. Reconstituted solutions degrade faster — use documented short-term storage windows.