Secretagogue research
Kisspeptin-10
Kisspeptin-10 is the C-terminally amidated decapeptide Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, the shortest widely studied active fragment of the KISS1 gene product (metastin). VaultLabs supplies it as a 5 mg lyophilised reference material for in vitro receptor and GnRH-axis research. It is not a medicine and is not for human or veterinary use.
Research use only. For in vitro research use only. Not for human or animal consumption. Not for human consumption, medical use, or personal application.
Reviewed by VaultLabs Research Editorial Desk · Last updated 2026-09-18
Key facts
- Sequence is Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (metastin 45–54 / Kp-10).
- CAS registry number 374675-21-5; molecular formula C63H83N17O14; molecular weight 1302.46 g/mol.
- Catalog presentation is a 5 mg lyophilised vial (VL-KP10-5), not a 10 mg fill.
- Foundational 2001 papers identified KiSS-1 peptides as ligands of GPR54 / KISS1R in cell systems.
- Kisspeptin-10 is a fragment, not the 54-residue metastin peptide; they are different analytical targets.
- Not an approved medicine in the UAE. VaultLabs supplies it only for laboratory research.
- Chemical name
- Kisspeptin-10 (metastin 45–54)
- Common synonyms
- Kp-10, metastin(45-54), KISS1 decapeptide fragment
- Sequence
- Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
- CAS number
- 374675-21-5
- Molecular formula
- C63H83N17O14
- Molecular weight
- 1302.46 g/mol
- Appearance
- White lyophilised powder
- Catalog strength
- 5 mg vial
What Kisspeptin-10 is
Kisspeptin-10 is ten residues with a C-terminal amide. The parent KISS1 product is processed to several C-terminal fragments; the decapeptide is the shortest fragment that the 2001 receptor papers treat as biologically active at GPR54. Catalog material is that synthetic amidated decapeptide, not the 145-residue precursor and not kisspeptin-54.
The C-terminal RF-amide is part of the identity. A free-acid analogue would be a different mass and a different analytical target. Confirm 1302.46 g/mol and the amide when the certificate lists modifications.
The 5 mg fill is easy to mis-pick against nearby 10 mg neuro and secretagogue vials. Strength is part of the identity on the purchase order. A 10 mg kisspeptin requisition does not match this SKU.
Where the research literature sits
Ohtaki, Shintani, Honda and colleagues reported in Nature (2001) that the KiSS-1 gene encodes a C-terminally amidated 54-residue peptide, isolated from placenta as the ligand of the orphan receptor hOT7T175 and named metastin. The paper is the origin of the ligand–receptor pairing.
Kotani, Detheux, Vandenbogaerde and colleagues reported in the Journal of Biological Chemistry (2001) that KiSS-1 encodes kisspeptins as the natural ligands of GPR54, and they characterised shorter C-terminal fragments — including the decapeptide — as active at that receptor in transfected cell systems. That is the paper that puts Kisspeptin-10, specifically, on the receptor.
Later neuroendocrine work places kisspeptin signalling upstream of GnRH in animal and cellular models. All of that literature is research context. It is not a human protocol and it does not make a 5 mg research vial a fertility medicine.
Analytical characterisation and handling
A 10-residue amidated peptide with tryptophan is routine HPLC work and a poor candidate for casual light exposure once in solution. Watch for des-amido material, methionine is not present, and the main oxidative risk is the tryptophan. Mass confirmation should match 1302.46 g/mol for the amide.
Store sealed lyophilised vials at 2–8 °C, protected from light and humidity, and equilibrate before opening. After reconstitution, prepare close to the point of use and log freeze-thaw cycles. Certified purity describes the cake, not an aged solution.
Do not file this certificate under a longer kisspeptin fragment or under a secretagogue such as tesamorelin. Receptor-class neighbours are not the same substance.
Regulatory position and supply
Kisspeptin-10 from VaultLabs is a research reference material. It is not a medicine, not a diagnostic reagent kit, and not supplied for human or veterinary use. Receptor literature does not change the supply classification.
The catalog SKU is a 5 mg lyophilised vial. Published certificates are retrieved through batch verification. Other secretagogue monographs on this site, including tesamorelin, describe different sequences.
How this page should be read
This article is for laboratory purchasers and documentation staff. It is not a protocol and not a substitute for institutional SOP review.
Cited papers identify the ligand and the receptor in experimental systems. They do not authorise human use of catalog material. Query mismatches between label, certificate and this page before opening the vial.
Research interest areas
GPR54 / KISS1R binding assays
GnRH-axis cell models (in vitro)
RF-amide peptide identity confirmation
Storage information
2–8 °C (lyophilized, sealed)
2–8 °C sealed lyophilized storage, protected from light and humidity.
Stability notes
Tryptophan-containing amidated decapeptide — protect solutions from unnecessary light and log freeze-thaw cycles.
Selected literature
Named papers behind the statements on this page. Each entry resolves on PubMed and through its DOI, so you can read the source rather than take our summary of it. Inclusion describes the research record and is not a claim about this material’s suitability for any use.
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor
Ohtaki T, et al. · Nature · 2001
Identifies the KiSS-1 product metastin as the endogenous ligand of hOT7T175 / GPR54 in cell and animal metastasis models.
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54
Kotani M, et al. · The Journal of Biological Chemistry · 2001
Characterises kisspeptin fragments, including the decapeptide, as GPR54 ligands in transfected cell systems.
Databases and verification
Registry and database entries for independent identity checks. These are standing searches rather than fixed records, so they stay current as new work is indexed.