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For in vitro research use only. Not for human or animal consumption.

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Growth-factor & metabolic research

IGF-1 LR3

IGF-1 LR3 (Long Arg3 IGF-1) is a modified insulin-like growth factor-1 analog carrying an N-terminal extension and an arginine substitution at position 3. It is studied in cell-culture potency and IGF-binding-protein interaction research. VaultLabs supplies IGF-1 LR3 as a lyophilised reference material for in vitro laboratory research only.

Research use only. For in vitro research use only. Not for human or animal consumption. Not for human consumption, medical use, or personal application.

Reviewed by VaultLabs Research Editorial Desk · Last updated 2026-08-04

Key facts

  • Long Arg3 IGF-1 analog; literature CAS registry number 946870-92-4.
  • Designed for reduced IGF-binding-protein affinity relative to native IGF-1 in recombinant research systems.
  • Catalog presentation is 100 mcg lyophilised research material with lot-linked HPLC certification when published.
  • Published work is preclinical and analytical — not an approved human medicine in the UAE.
  • Supplied strictly for in vitro laboratory research; not for human or veterinary use.
Chemical name
IGF-1 LR3 (Long Arg3 IGF-1)
Common synonyms
Long R3 IGF-I, IGF1 LR3, Arg3 IGF-1 analog
CAS number
946870-92-4
Structural class
Modified IGF-1 analog peptide
Appearance
White lyophilised powder
Catalog strength
100 mcg vial

What IGF-1 LR3 is

IGF-1 LR3 is a recombinant research analog of insulin-like growth factor-1. The Long Arg3 design combines an N-terminal extension with an arginine substitution at position 3, which reduces binding to IGF-binding proteins in the systems where that property was originally characterised.

For a purchasing laboratory the practical identity question is the analog designation on the certificate — LongR3 versus native IGF-1 versus truncated Des(1-3) forms — because those species are analytically distinct.

VaultLabs catalogs a 100 mcg lyophilised presentation for in vitro workflows. That fill mass is typical of growth-factor reference use rather than bulk reagent supply.

Where the research literature sits

Foundational characterisation of Long Arg3 fusion analogs comes from early-1990s recombinant IGF research describing potency relative to native IGF-1 in cell systems that secrete IGF-binding proteins.

A later analytical strand addresses detection of LongR3 and related analogs in anti-doping and forensic contexts, which is a legitimate laboratory use case for characterised reference material.

VaultLabs makes no claims about physiological or clinical effects and does not supply this material for human use.

Analytical characterisation and handling

Release is by HPLC against a stated purity specification with a lot-linked certificate. Growth-factor analogs benefit from mass confirmation where instrumentation allows, because truncated or oxidised forms can co-elute under non-optimised methods.

Store sealed lyophilised vials at 2–8 °C, protected from light and humidity, and equilibrate to room temperature before opening. Reconstitute gently and minimise freeze-thaw cycles.

IGF-1 LR3 is not an approved medicine and is not supplied for human or veterinary use.

Regulatory position and supply

VaultLabs IGF-1 LR3 is a research reference material for in vitro laboratory use only. Orders are accepted against a research-use declaration retained in the order record.

The catalog presentation is a 100 mcg lyophilised vial with lot-linked certificate retrieval through batch verification when published.

Laboratory documentation practice

Laboratories comparing IGF analogs should treat LongR3, R3 and Des(1-3) forms as distinct analytical targets rather than interchangeable stock codes. Incoming-goods checks that confirm mass and chromatographic identity reduce the risk of mixing those forms in a shared freezer inventory.

UAE dispatch uses temperature-aware packaging where configured; the transfer from courier to laboratory cold storage remains the weakest point in Gulf summer conditions and is worth documenting as a receipt step. VaultLabs does not provide reconstitution recipes for human use and will not advise on administration under any circumstance.

Procurement records should retain the lot number, certificate reference and research-use declaration. Those artefacts are what an institutional audit will ask for if the material later appears in a methods appendix or materials list.

How this page should be read

This monograph is a reference article for laboratory purchasers and documentation staff. It summarises chemical identity, literature context and handling constraints that affect analytical work. It is not a protocol, not a dosing guide and not a substitute for institutional SOP review.

Where pharmaceutical or clinical papers are cited, they are included only to anchor compound identity and regulatory status. They do not authorise human use of VaultLabs research material, and they do not convert a lyophilised reference vial into a finished medicine.

If a certificate, label and monograph appear to disagree, stop and query support with the lot number before the material enters an experiment. Lot-linked certificates override general catalog copy for the specific unit in hand.

VaultLabs updates monographs when catalog strengths or documentation practice change. The updatedAt field marks the editorial revision date for this article, not the manufacture date of any particular lot.

All VaultLabs materials named here remain research-use-only: not for human consumption, not for medical use, and not for personal application under any reading of the surrounding literature.

Research interest areas

IGF receptor binding assays

IGF-binding protein interaction studies

Cell-culture growth-factor panels

Analytical method development for IGF analogs

Storage information

2–8 °C (lyophilized, sealed)

2–8 °C sealed lyophilized storage; protect from light and moisture.

Stability notes

Growth-factor analogs require sealed cold storage and careful reconstitution to avoid aggregation. Verify integrity via COA HPLC before incorporation into long-running assays.

Selected literature

Named papers behind the statements on this page. Each entry resolves on PubMed and through its DOI, so you can read the source rather than take our summary of it. Inclusion describes the research record and is not a claim about this material’s suitability for any use.

  1. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency

    Francis GL, et al. · Journal of Molecular Endocrinology · 1992

    Foundational characterisation of Long Arg3 IGF-I fusion analogues and IGFBP interaction in cell systems.

    PubMed 1378742doi:10.1677/jme.0.0080213

  2. Detection of LongR3-IGF-I, Des(1-3)-IGF-I, and R3-IGF-I using immunopurification and high resolution mass spectrometry for antidoping purposes

    Mongongu C, et al. · Drug Testing and Analysis · 2021

    Analytical reference for distinguishing LongR3 IGF-I from related analogs in laboratory detection workflows.

    PubMed 33587816doi:10.1002/dta.3011

Databases and verification

Registry and database entries for independent identity checks. These are standing searches rather than fixed records, so they stay current as new work is indexed.

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